Minding Reality
Nostalgia assuages spatial anxiety
Alice Oliver et al.
Journal of Experimental Social Psychology, May 2024
Abstract:
According to the regulatory model of nostalgia, the emotion is triggered by adverse psychological and physical experiences. Nostalgia, in turn, serves to counter those negative states. We extend this model to encompass spatial anxiety, that is, apprehension and disorientation during environmental navigation. In Experiment 1, we induced spatial anxiety by training participants to navigate a route in a virtual maze and then surreptitiously changing part of the previously learned route (spatial-anxiety condition) or leaving the route unchanged (neutral condition). Consistent with the regulatory model, spatial anxiety (compared to the neutral condition) triggered nostalgia. In Experiments 2-3, we displayed nostalgic (nostalgia condition) or matched control (control condition) pictures on the walls of a virtual maze. Participants navigated the maze passively (video clip, Experiment 2) or actively (computer-based task, Experiment 3) and then reported their spatial anxiety. Supporting the regulatory model, nostalgia (compared to control) reduced spatial anxiety (Experiments 2-3) and this, in turn, predicted higher goal setting (Experiment 3). Nostalgia assuages spatial anxiety during environmental navigation.
A chemical signal in human female tears lowers aggression in males
Shani Agron et al.
PLoS ONE, December 2023
Abstract:
Rodent tears contain social chemosignals with diverse effects, including blocking male aggression. Human tears also contain a chemosignal that lowers male testosterone, but its behavioral significance was unclear. Because reduced testosterone is associated with reduced aggression, we tested the hypothesis that human tears act like rodent tears to block male aggression. Using a standard behavioral paradigm, we found that sniffing emotional tears with no odor percept reduced human male aggression by 43.7%. To probe the peripheral brain substrates of this effect, we applied tears to 62 human olfactory receptors in vitro. We identified 4 receptors that responded in a dose-dependent manner to this stimulus. Finally, to probe the central brain substrates of this effect, we repeated the experiment concurrent with functional brain imaging. We found that sniffing tears increased functional connectivity between the neural substrates of olfaction and aggression, reducing overall levels of neural activity in the latter. Taken together, our results imply that like in rodents, a human tear-bound chemosignal lowers male aggression, a mechanism that likely relies on the structural and functional overlap in the brain substrates of olfaction and aggression. We suggest that tears are a mammalian-wide mechanism that provides a chemical blanket protecting against aggression.
Does Pain Hurt More in Spanish? The Neurobiology of Pain among Spanish-English Bilingual Adults
Morgan Gianola, Maria Llabre & Elizabeth Losin
Social Cognitive and Affective Neuroscience, forthcoming
Abstract:
We previously found Spanish-English bilingual adults reported higher pain intensity when exposed to painful heat in the language of their stronger cultural orientation. Here, we elucidate brain systems involved in language-driven alterations in pain responses. During separate English- and Spanish-speaking fMRI scanning runs, 39 (21 female) bilingual adults rated painful heat intermixed between culturally evocative images and completed sentence reading tasks. Surveys of cultural identity and language use measured relative preference for US-American vs Hispanic culture (cultural orientation). Participants produced higher intensity ratings in Spanish compared to English. Group-level whole-brain differences in pain-evoked activity between languages emerged in somatosensory, cingulate, precuneus, and cerebellar cortex. Regions of interest associated with semantic, attention, and somatosensory processing showed higher average pain-evoked responses in participants' culturally preferred language, as did expression of a multivariate pain-predictive pattern. Follow-up moderated mediation analyses showed somatosensory activity mediated language effects on pain intensity, particularly for Hispanic oriented participants. These findings relate to distinct ("meddler", "spotlight", and "inducer") hypotheses about the nature of language effects on perception and cognition. Knowledge of language influences on pain could improve efficacy of culturally sensitive treatment approaches across the diversity of Hispanic adults to mitigate documented health disparities in this population.
Social anxiety disorder-associated gut microbiota increases social fear
Nathaniel Ritz et al.
Proceedings of the National Academy of Sciences, 2 January 2024
Abstract:
Social anxiety disorder (SAD) is a crippling psychiatric disorder characterized by intense fear or anxiety in social situations and their avoidance. However, the underlying biology of SAD is unclear and better treatments are needed. Recently, the gut microbiota has emerged as a key regulator of both brain and behaviour, especially those related to social function. Moreover, increasing data supports a role for immune function and oxytocin signalling in social responses. To investigate whether the gut microbiota plays a causal role in modulating behaviours relevant to SAD, we transplanted the microbiota from SAD patients, which was identified by 16S rRNA sequencing to be of a differential composition compared to healthy controls, to mice. Although the mice that received the SAD microbiota had normal behaviours across a battery of tests designed to assess depression and general anxiety-like behaviours, they had a specific heightened sensitivity to social fear, a model of SAD. This distinct heightened social fear response was coupled with changes in central and peripheral immune function and oxytocin expression in the bed nucleus of the stria terminalis. This work demonstrates an interkingdom basis for social fear responses and posits the microbiome as a potential therapeutic target for SAD.
Self-regulating arousal via pupil-based biofeedback
Sarah Nadine Meissner et al.
Nature Human Behaviour, forthcoming
Abstract:
The brain's arousal state is controlled by several neuromodulatory nuclei known to substantially influence cognition and mental well-being. Here we investigate whether human participants can gain volitional control of their arousal state using a pupil-based biofeedback approach. Our approach inverts a mechanism suggested by previous literature that links activity of the locus coeruleus, one of the key regulators of central arousal and pupil dynamics. We show that pupil-based biofeedback enables participants to acquire volitional control of pupil size. Applying pupil self-regulation systematically modulates activity of the locus coeruleus and other brainstem structures involved in arousal control. Furthermore, it modulates cardiovascular measures such as heart rate, and behavioural and psychophysiological responses during an oddball task. We provide evidence that pupil-based biofeedback makes the brain's arousal system accessible to volitional control, a finding that has tremendous potential for translation to behavioural and clinical applications across various domains, including stress-related and anxiety disorders.
Individuals who see the good in the bad engage distinctive default network coordination during post-encoding rest
Siddhant Iyer et al.
Proceedings of the National Academy of Sciences, 2 January 2024
Abstract:
Focusing on the upside of negative events often promotes resilience. Yet, the underlying mechanisms that allow some people to spontaneously see the good in the bad remain unclear. The broaden-and-build theory of positive emotion has long suggested that positive affect, including positivity in the face of negative events, is linked to idiosyncratic thought patterns (i.e., atypical cognitive responses). Yet, evidence in support of this view has been limited, in part, due to difficulty in measuring idiosyncratic cognitive processes as they unfold. To overcome this barrier, we applied Inter-Subject Representational Similarity Analysis to test whether and how idiosyncratic neural responding supports positive reactions to negative experience. We found that idiosyncratic functional connectivity patterns in the brain's default network while resting after a negative experience predicts more positive descriptions of the event. This effect persisted when controlling for connectivity 1) before and during the negative experience, 2) before, during, and after a neutral experience, and 3) between other relevant brain regions (i.e., the limbic system). The relationship between idiosyncratic default network responding and positive affect was largely driven by functional connectivity patterns between the ventromedial prefrontal cortex and the rest of the default network and occurred relatively quickly during rest. We identified post-encoding rest as a key moment and the default network as a key brain system in which idiosyncratic responses correspond with seeing the good in the bad.
When secrets come to mind: Preoccupation, suppression and engagement
Christopher Davis, George Wright & Cassandra McMillan
European Journal of Social Psychology, forthcoming
Abstract:
When secrets come to mind, do people try to suppress them or do they engage with them? Whereas earlier research suggested that people try to suppress secrets, recent work suggests that people often engage with their secrets. Although thought suppression tends to be associated with greater distress, engagement may be ameliorative. In two longitudinal studies of 653 adults (55% women; Mage = 41.3, SD = 12.4) keeping a secret from their partner, we show that engagement with and suppression of secrets are highly positively related. Like suppression, the more people engage with secrets, the more negative affect and guilt they report feeling. Longitudinal analyses indicate that whereas changes over time in engagement and suppression both predicted reduced secret preoccupation, reductions in suppression (but not engagement) mediated reductions in guilt and negative affect. These results indicate that suppression and engagement are more intimately connected than previously thought. We found no evidence that engagement was ameliorative.