Almost nobody is taking America's drug crisis seriously. We talk about it plenty, but that talk rarely acknowledges what distinguishes today's drug epidemic from past ones: Those earlier crises inflicted many more or less equally weighty harms — to users' health, to families, to communities. In this crisis, one problem dwarfs all others: death. Drugs have changed, probably for good. They now kill their users. A haphazard public response was more tolerable when the harms of drug use were more spread out and took time to accumulate. But with tens of thousands poisoned to death every year, bolder action is required.