Call me crazy
Peter Rentfrow et al.
Journal of Personality and Social Psychology, forthcoming
Abstract:
There is overwhelming evidence for regional variation across the United States on a range of key political, economic, social, and health indicators. However, a substantial body of research suggests that activities in each of these domains are typically influenced by psychological variables, raising the possibility that psychological forces might be the mediating or causal factors responsible for regional variation in the key indicators. Thus, the present article examined whether configurations of psychological variables, in this case personality traits, can usefully be used to segment the country. Do regions emerge that can be defined in terms of their characteristic personality profiles? How are those regions distributed geographically? And are they associated with particular patterns of key political, economic, social, and health indicators? Results from cluster analyses of 5 independent samples totaling over 1.5 million individuals identified 3 robust psychological profiles: Friendly & Conventional, Relaxed & Creative, and Temperamental & Uninhibited. The psychological profiles were found to cluster geographically and displayed unique patterns of associations with key geographical indicators. The findings demonstrate the value of a geographical perspective in unpacking the connections between microlevel processes and consequential macrolevel outcomes.
----------------------
Sander Koole, Mandy Tjew A Sin & Iris Schneider
Psychological Science, forthcoming
Abstract:
Individuals with low (rather than high) self-esteem often struggle with existential concerns. In the present research, we examined whether these existential concerns may be alleviated by seemingly trivial experiences of both real and simulated interpersonal touch. A brief touch on the shoulder by a female experimenter led individuals with low self-esteem to experience less death anxiety (Study 1) and more social connectedness after a death reminder (Study 2). Reminding individuals with low self-esteem of death increased their desire for touch, as indicated by higher value estimates of a teddy bear, a toy animal that simulates interpersonal touch (Study 3). Finally, holding a teddy bear (vs. a cardboard box) led individuals with low self-esteem to respond to a death reminder with less defensive ethnocentrism (Study 4). Individuals with high self-esteem were unaffected by touch (Studies 1-4). These findings highlight the existential significance of embodied touch experiences, particularly for individuals with low self-esteem.
----------------------
Race and Schizophrenia Diagnoses in Four Types of Hospitals
Arnold Barnes
Journal of Black Studies, September 2013, Pages 665-681
Abstract:
Overdiagnosis of schizophrenia is a mental health disparity that negatively affects Black clients in terms of increased risk of hospitalization and incorrect drug therapy. The present study investigated the extent of overdiagnosis in four different types of hospitals and client characteristics associated with this disparity. Data on 1,641 inpatient clients from a national survey were analyzed. Results revealed that in each type of hospital, Black clients were more likely than White clients to be diagnosed with schizophrenia rather than a mood disorder. After controlling for the influence of client clinical and demographic variables, client race was the most significant predictor of schizophrenia diagnoses in the hospitals collectively. These findings further document the need for initiatives to address this disparity.
----------------------
Dawne Mouzon
Social Science Research, forthcoming
Abstract:
African Americans typically exhibit similar or better mental health outcomes than whites, an unexpected pattern given their disproportionate exposure to psychosocial stressors. The "race paradox in mental health" has been attributed to presumed stronger social ties among blacks but there is scarce empirical research in this regard. Using data from the 2001-2003 National Survey of American Life (N = 4,086), I test whether more abundant and higher quality friendships and fictive kin relationships among African Americans (if they exist) account for the race paradox in mental health. I find few race differences in the quantity and quality of friendships and fictive kinships and these differences did not explain the race paradox in mental health. Future research should investigate other potential resilience mechanisms among African Americans to explain their relatively positive mental health outcomes.
----------------------
Antidepressant Use and Method of Suicide in the United States: Variation by Age and Sex, 1998-2007
Julie Phillips & Colleen Nugent
Archives of Suicide Research, Fall 2013, Pages 360-372
Abstract:
This study examines the association between antidepressant use and suicide rates, by sex, age, and method of suicide, between 1998 and 2007 in the United States. Overall suicide rates for the young and elderly declined but rates for the middle-aged increased. All age groups experienced increases in antidepressant use. The elderly exhibited the largest increase in antidepressant usage and biggest declines in suicide rates. Firearm suicides for men and women declined but suicide by drug poisoning rose, particularly for women. For young males and elderly males and females, better treatment of severe depression may have contributed to declining suicide rates. However, rising rates of prescription drug use are associated with higher levels of suicide by drug poisoning.
----------------------
Human genome-guided identification of memory-modulating drugs
Andreas Papassotiropoulos et al.
Proceedings of the National Academy of Sciences, 12 November 2013, Pages E4369-E4374
Abstract:
In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this knowledge can be used as a starting point for drug identification, one of the central hopes of the human genome project. The aim of the present study was to identify memory-modulating compounds through the use of human genetic information. We performed a multinational collaborative study, which included assessment of aversive memory - a trait central to posttraumatic stress disorder - and a gene-set analysis in healthy individuals. We identified 20 potential drug target genes in two genomewide-corrected gene sets: the neuroactive ligand-receptor interaction and the long-term depression gene set. In a subsequent double-blind, placebo-controlled study in healthy volunteers, we aimed at providing a proof of concept for the genome-guided identification of memory modulating compounds. Pharmacological intervention at the neuroactive ligand-receptor interaction gene set led to significant reduction of aversive memory. The findings demonstrate that genome information, along with appropriate data mining methodology, can be used as a starting point for the identification of memory-modulating compounds.
----------------------
Saving Can Save from Death Anxiety: Mortality Salience and Financial Decision-Making
Tomasz Zaleskiewicz, Agata Gasiorowska & Pelin Kesebir
PLoS ONE, November 2013
Abstract:
Four studies tested the idea that saving money can buffer death anxiety and constitute a more effective buffer than spending money. Saving can relieve future-related anxiety and provide people with a sense of control over their fate, thereby rendering death thoughts less threatening. Study 1 found that participants primed with both saving and spending reported lower death fear than controls. Saving primes, however, were associated with significantly lower death fear than spending primes. Study 2 demonstrated that mortality primes increase the attractiveness of more frugal behaviors in save-or-spend dilemmas. Studies 3 and 4 found, in two different cultures (Polish and American), that the activation of death thoughts prompts people to allocate money to saving as opposed to spending. Overall, these studies provided evidence that saving protects from existential anxiety, and probably more so than spending.
----------------------
Written Exposure Therapy for Veterans Diagnosed with PTSD: A Pilot Study
Denise Sloan et al.
Journal of Traumatic Stress, forthcoming
Abstract:
There is a need to identify alternative treatment options for posttraumatic stress disorder (PTSD), especially among veterans where PTSD tends to be more difficult to treat and dropout rates are especially high. One potential alternative is written exposure therapy, a brief intervention shown to treat PTSD among civilians effectively. This study investigated the feasibility and tolerability of written exposure therapy in an uncontrolled trial with a sample of 7 male veterans diagnosed with PTSD. Findings indicated that written exposure therapy was well tolerated and well received. Only 1 of the 7 veterans dropped out of treatment, no adverse events occurred during the course of treatment, and veterans provided high treatment satisfaction ratings. Clinically significant improvements in PTSD symptom severity were observed for 4 veterans at posttreatment and 6 veterans at the 3-month follow up. Moreover, 5 of the 7 veterans no longer met diagnostic criteria for PTSD 3 months following treatment. These findings suggest that written exposure therapy holds promise as a brief, well tolerated treatment for veterans with PTSD. However, additional research using randomized controlled trial methodology is needed to confirm its efficacy.
----------------------
Casual Sexual Relationships and Mental Health in Adolescence and Emerging Adulthood
Sara Sandberg-Thoma & Claire Kamp Dush
Journal of Sex Research, forthcoming
Abstract:
Casual sexual relationships are relatively common in emerging adulthood. Yet the mental health implications of engaging in these relationships are unclear; past research has found negative associations, positive associations, or no association with mental health. In addition, little research has accounted for mental health status prior to entering casual sexual relationships. Using data from the National Longitudinal Study of Adolescent Health (N = 12,401), we measured mental health prior to engaging in casual sexual relationships and subsequent mental health after engaging in these relationships. We found that suicidal ideation and depressive symptoms in adolescence were associated with entrance into casual sexual relationships in emerging adulthood. Furthermore, casual sexual relationships were associated with an increased likelihood of reporting suicidal ideation in emerging adulthood.
----------------------
Sex Differences and Emotion Regulation: An Event-Related Potential Study
Elyse Gardener et al.
PLoS ONE, October 2013
Abstract:
Difficulties in emotion regulation have been implicated as a potential mechanism underlying anxiety and mood disorders. It is possible that sex differences in emotion regulation may contribute towards the heightened female prevalence for these disorders. Previous fMRI studies of sex differences in emotion regulation have shown mixed results, possibly due to difficulties in discriminating the component processes of early emotional reactivity and emotion regulation. The present study used event-related potentials (ERPs) to examine sex differences in N1 and N2 components (reflecting early emotional reactivity) and P3 and LPP components (reflecting emotion regulation). N1, N2, P3, and LPP were recorded from 20 men and 23 women who were instructed to "increase," "decrease," and "maintain" their emotional response during passive viewing of negative images. Results indicated that women had significantly greater N1 and N2 amplitudes (reflecting early emotional reactivity) to negative stimuli than men, supporting a female negativity bias. LPP amplitudes increased to the "increase" instruction, and women displayed greater LPP amplitudes than men to the "increase" instruction. There were no differences to the "decrease" instruction in women or men. These findings confirm predictions of the female negativity bias hypothesis and suggest that women have greater up-regulation of emotional responses to negative stimuli. This finding is highly significant in light of the female vulnerability for developing anxiety disorders.
----------------------
James Li, Michele Berk & Steve Lee
Development and Psychopathology, November 2013, Pages 991-1003
Abstract:
Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors.
----------------------
The risk of unintended pregnancy among young women with mental health symptoms
Kelli Stidham Hall et al.
Social Science & Medicine, forthcoming
Abstract:
Depression and stress have been linked with poor contraceptive behavior, but whether existing mental health symptoms influence women's subsequent risk of unintended pregnancy is unclear. We prospectively examined the effect of depression and stress symptoms on young women's pregnancy risk over one year. We used panel data from a longitudinal study of 992 U.S. women ages 18-20 years who reported a strong desire to avoid pregnancy. Weekly journal surveys measured relationship, contraceptive use and pregnancy outcomes. We examined 27,572 journal surveys from 940 women over the first study year. Our outcome was self-reported pregnancy. At baseline, we assessed moderate/severe depression (CESD-5) and stress (PSS-4) symptoms. We estimated the effect of baseline mental health symptoms on pregnancy risk with discrete-time, mixed-effects, proportional hazard models using logistic regression. At baseline, 24% and 23% of women reported moderate/severe depression and stress symptoms, respectively. Ten percent of young women not intending pregnancy became pregnant during the study. Rates of pregnancy were higher among women with baseline depression (14% vs. 9%, p=0.04) and stress (15% vs. 9%, p=0.03) compared to women without symptoms. In multivariable models, the risk of pregnancy was 1.6 times higher among women with stress symptoms compared to those without stress (aRR 1.6, CI 1.1,2.7). Women with co-occurring stress and depression symptoms had over twice the risk of pregnancy (aRR 2.1, CI 1.1,3.8) compared to those without symptoms. Among women without a prior pregnancy, having co-occurring stress and depression symptoms was the strongest predictor of subsequent pregnancy (aRR 2.3, CI 1.2,4.3), while stress alone was the strongest predictor among women with a prior pregnancy (aRR 3.0, CI 1.1,8.8). Depression symptoms were not independently associated with young women's pregnancy risk. In conclusion, stress, and especially co-occurring stress and depression symptoms, consistently and adversely influenced these young women's risk of unintended pregnancy over one year.
----------------------
Purpose in Life Predicts Better Emotional Recovery from Negative Stimuli
Stacey Schaefer et al.
PLoS ONE, November 2013
Abstract:
Purpose in life predicts both health and longevity suggesting that the ability to find meaning from life's experiences, especially when confronting life's challenges, may be a mechanism underlying resilience. Having purpose in life may motivate reframing stressful situations to deal with them more productively, thereby facilitating recovery from stress and trauma. In turn, enhanced ability to recover from negative events may allow a person to achieve or maintain a feeling of greater purpose in life over time. In a large sample of adults (aged 36-84 years) from the MIDUS study (Midlife in the U.S., http://www.midus.wisc.edu/), we tested whether purpose in life was associated with better emotional recovery following exposure to negative picture stimuli indexed by the magnitude of the eyeblink startle reflex (EBR), a measure sensitive to emotional state. We differentiated between initial emotional reactivity (during stimulus presentation) and emotional recovery (occurring after stimulus offset). Greater purpose in life, assessed over two years prior, predicted better recovery from negative stimuli indexed by a smaller eyeblink after negative pictures offset, even after controlling for initial reactivity to the stimuli during the picture presentation, gender, age, trait affect, and other well-being dimensions. These data suggest a proximal mechanism by which purpose in life may afford protection from negative events and confer resilience is through enhanced automatic emotion regulation after negative emotional provocation.
----------------------
Stress and the healthy adolescent brain: Evidence for the neural embedding of life events
Barbara Ganzel et al.
Development and Psychopathology, November 2013, Pages 879-889
Abstract:
Little is known about the long-term neural consequences of adverse life events for healthy adolescents, and this is particularly the case for events that occur after a putative stress-sensitive period in early childhood. In this functional magnetic resonance imaging study of healthy adolescents, we found that prior exposure to severe adverse life events was associated with current anxiety and with increased amygdala reactivity to standardized emotional stimuli (viewing of fearful faces relative to calm ones). Conjunction analyses identified multiple regions, including the amygdala, insula, and prefrontal cortex, in which reactivity to emotional faces covaried with life events as well as with current anxiety. Our morphometric analyses suggest systemic alterations in structural brain development with an association between anxiety symptoms and global gray matter volume. No life events were reported for the period before 4 years of age, suggesting that these results were not driven by exposure to stress during an early sensitive period in development. Overall, these data suggest systemic effects of traumatic events on the dynamically developing brain that are present even in a nonclinical sample of adolescents.
----------------------
Allison Troy, Amanda Shallcross & Iris Mauss
Psychological Science, forthcoming
Abstract:
Emotion regulation is central to psychological health. For instance, cognitive reappraisal (reframing an emotional situation) is generally an adaptive emotion-regulation strategy (i.e., it is associated with increased psychological health). However, a person-by-situation approach suggests that the adaptiveness of different emotion-regulation strategies depends on the context in which they are used. Specifically, reappraisal may be adaptive when stressors are uncontrollable (when the person can regulate only the self) but maladaptive when stressors can be controlled (when the person can change the situation). To test this prediction, we measured cognitive-reappraisal ability, the severity of recent life stressors, stressor controllability, and level of depression in 170 participants. For participants with uncontrollable stress, higher cognitive-reappraisal ability was associated with lower levels of depression. In contrast, for participants with controllable stress, higher cognitive-reappraisal ability was associated with greater levels of depression. These findings support a theoretical model in which particular emotion-regulation strategies are not adaptive or maladaptive per se; rather, their adaptiveness depends on the context.
----------------------
Nicholas Kelley, David Tang & Brandon Schmeichel
Cognition & Emotion, forthcoming
Abstract:
Death is inevitable. One way people cope with awareness of death is to focus on the positive things in life. Consistent with this idea, reminders of personal mortality have been found to increase optimism and tune attention towards positive information. The current research tested the hypothesis that persons higher in trait self-control are especially likely to attend to positive (versus negative) stimuli under mortality salience (MS). Participants completed a measure of trait self-control, contemplated their own mortality or a control topic, and then viewed positive and negative affective images while their gaze patterns were recorded. MS increased the attention to positive (versus negative) images among participants higher in trait self-control, whereas those lower in trait self-control exhibited a non-significant trend in the opposite direction. Thus, participants higher in trait self-control showed a positivity bias after contemplating death, which may help explain why they tend to enjoy more positive outcomes in life.
----------------------
Unemployment, Medicaid provisions, the mental health industry, and suicide
Lawrence Pellegrini & Rosa Rodriguez-Monguio
Social Science Journal, forthcoming
Abstract:
This study examines the association between unemployment, Medicaid provisions, the mental health industry, and adult suicides in nine US northeastern states from 1999 to 2009. Results show that increased unemployment is associated with more Medicaid beneficiaries and higher health care spending per beneficiary with no significant relationship with Medicaid mental health spending. The Medicaid beneficiary rate is positively associated with the number of mental health clinics, mental health and substance abuse social workers, mental health counselors, and psychiatrists, with no significant association with mental health physician offices or psychologists. Unemployment is also related with increasing suicide rates for the overall population and White non-Hispanics, aged 16-64, with the worst association for White non-Hispanic males. The composition of the mental health industry is also associated with suicide rates. Maintaining an appropriate mix of mental health facilities and professionals to prevent, diagnose, and treat mental health disorders remains a critical public health challenge.
----------------------
Wendy D'Andrea et al.
International Journal of Psychophysiology, October 2013, Pages 80-89
Abstract:
Research on threat responses, particularly among trauma-exposed individuals, has traditionally focused on increased autonomic arousal and reactivity. However, clinical features associated with trauma exposure, such as dissociation (e.g., shutting down or "spacing out") manifest as the opposite pattern: non-reactivity and blunted arousal. These clinical features suggest that the possibility of threat responses other than fight/flight, namely, immobilization may be undergirded by hyper- or hypo-arousal. The goal of this paper is to examine autonomic responses to a stressful stimulus (acoustic startle) using analytic approaches which have been previously used to examine defensive responses before: heart rate acceleration, heart rate deceleration, and skin conductance response. We examined these responses in relation to symptoms (Posttraumatic Stress Disorder, or PTSD, and dissociation) and trauma exposure (cumulative exposure, age of onset) in a sample of trauma-exposed college students. We found evidence of blunted reactivity, with decreased acceleration and skin conductance, but with increased deceleration, particularly among individuals who had significant symptoms and early exposure to multiple types of trauma. However, individuals with sub-clinical symptoms and more attenuated exposure had large heart rate acceleration and skin conductance responses during the task. Taken together, these findings suggest that moderate symptoms and trauma exposure are related to exaggerated autonomic responses, while extreme symptoms and trauma exposure are related to blunted autonomic responses. These findings further suggest heterogeneity of stress responses within individuals with PTSD and with trauma exposure.
----------------------
Cortisol at the emergency room rape visit as a predictor of PTSD and depression symptoms over time
Kate Walsh et al.
Psychoneuroendocrinology, November 2013, Pages 2520-2528
Background: Dysregulation of the hypothalamic-pituitary-adrenal axis, typically reflected by alterations in cortisol responsivity, has been associated with exposure to traumatic events and the development of stress-related disorders such as posttraumatic stress disorder (PTSD) and depression.
Methods: Serum cortisol was measured at the time of a post sexual assault medical exam among a sample of 323 female victims of recent sexual assault. Analyses were conducted among 235 participants who provided data regarding history of previous assault as well as PTSD and depression symptoms during at least one of the three follow-ups.
Results: Growth curve models suggested that prior history of assault and serum cortisol were positively associated with the intercept and negatively associated with the slope of PTSD and depression symptoms after controlling for covariates. Prior history of assault and serum cortisol also interacted to predict the intercept and slope of PTSD and depression symptoms such that women with a prior history of assault and lower ER cortisol had higher initial symptoms that decreased at a slower rate relative to women without a prior history and those with higher ER cortisol.
Conclusions: Prior history of assault was associated with diminished acute cortisol responsivity at the emergency room visit. Prior assault history and cortisol both independently and interactively predicted PTSD and depression symptoms at first follow-up and over the course a 6-month follow-up.
----------------------
The efficacy of interpersonal psychotherapy for depression among economically disadvantaged mothers
Sheree Toth et al.
Development and Psychopathology, November 2013, Pages 1065-1078
Abstract:
A randomized clinical trial was conducted to evaluate the efficacy of interpersonal psychotherapy (IPT) for ethnically and racially diverse, economically disadvantaged women with major depressive disorder. Non-treatment-seeking urban women (N = 128; M age = 25.40, SD = 4.98) with infants were recruited from the community. Participants were at or below the poverty level: 59.4% were Black and 21.1% were Hispanic. Women were screened for depressive symptoms using the Center for Epidemiologic Studies Depression Scale; the Diagnostic Interview Schedule was used to confirm major depressive disorder diagnosis. Participants were randomized to individual IPT or enhanced community standard. Depressive symptoms were assessed before, after, and 8 months posttreatment with the Beck Depression Inventory-II and the Revised Hamilton Rating Scale for Depression. The Social Support Behaviors Scale, the Social Adjustment Scale-Self-Report, and the Perceived Stress Scale were administered to examine mediators of outcome at follow-up. Treatment effects were evaluated with a growth mixture model for randomized trials using complier-average causal effect estimation. Depressive symptoms trajectories from baseline through postintervention to follow-up showed significant decreases among the IPT group compared to the enhanced community standard group. Changes on the Perceived Stress Scale and the Social Support Behaviors Scale mediated sustained treatment outcome.